Original Article

J Minim Invasive Surg 2012; 15(4): 126-132

Published online December 15, 2012

https://doi.org/10.7602/jmis.2012.15.4.126

© The Korean Society of Endo-Laparoscopic & Robotic Surgery

대장암 진단을 받은 75세 이상의 환자군에서의 복강경 수술의 유용성

이강산ㆍ김영완ㆍ김주희ㆍ권현준ㆍ김익용

연세대학교 원주의과대학 외과학교실

Received: August 24, 2012; Revised: October 13, 2012; Accepted: October 16, 2012

Can Elderly Patients Older than 75 Years with Colorectal Cancer Tolerate Planned Laparoscopic Surgery?

Kang San Lee, M.D., Young Wan Kim, M.D., Joo Hee Kim, M.D., Hyun Jun Kwon, R.N., Ik Yong Kim, M.D.

Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea

Correspondence to : Ik Yong Kim
Department of Surgery, Yonsei University Wonju College of Medicine, 162, Ilsan-dong, Wonju 220-701, Korea
Tel:+82-33-741-0575, Fax:+82-33-744-6604 E-mail:iykim@yonsei.ac.kr

Received: August 24, 2012; Revised: October 13, 2012; Accepted: October 16, 2012

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Purpose: Colorectal resection for elderly patients is associated with significant morbidity and mortality. It is still unclear whether or not laparoscopic colorectal resection (Lap CR) is indicated in elderly patients. The aim of this study is to evaluate the outcome of colonic surgery in elderly patients and to assess the feasibility and safety of laparoscopic colorectal surgery in elderly patients.
Methods: Patient characteristics and perioperative and pathologic data on 295 patients who underwent Lap CR for cancer from Jan. 2004 to Aug. 2011 were prospectively collected. Exclusion criteria were emergency and palliative bypass surgery. Outcomes for elderly patients (≥75 years) were compared with those of younger patients (<75 years).
Results: In comparison of 257 younger patients (<75 years, median age 61 years), 38 elderly patients (≥75 years, median age 79 years) showed a greater proportion off emale gender (52.6% vs. 37.0%, p=0.065) and American Society of Anesthesiologists score 2∼3 (97.3% vs.42.0%, p<0.001). No differences in tumor location, median operative time, conversion rate, duration of hospital stay, and perioperative complications (23.7% vs. 30.0%, p=0.427) were observed between the two groups. Distributions of American Joint Committee on Cancer stages and number of harvested lymph nodes were comparable between groups.
Conclusion: Although elderly patients are more likely to be affected by co morbidities, postoperative outcome in this group after Lap CR is comparable with that of younger patients. Use of Lap CR in elderly patients is safe, and is associated with a low morbidity. It should be also regarded as the optimal approach for very elderly patients.

Keywords Colorectal cancer, Laparoscopy, Elderly, Safety, Complication

  1. Statistics Korea. Population Projections for Korea: 2010-2060 , Statistical Publications 2012;B81303;378. http://kostatat.go.kr
  2. Ministry for Heath, Welfare a nd Family Affairs. Annual report of cancer incidence 2009 and survival 1999 ∼ 2009 in Korea. 2011;10154.
  3. Mamidanna R, Eid-Arimoku L, Almoudaris AM, et al. Poor 1-year survival in elderly patients undergoing non elective colorectal resection. Dis Co lon Rectum 2012;55:788-796.
    Pubmed CrossRef
  4. Minardi A, Sittig KM, Zibari GB, McDonald JC. Colorectal cancer in the young patient. Am Surg 1998;64:849-853.
    Pubmed
  5. Lee JM, Kim HC, Park IJ, Kim DD, Yu CS, Kim JC. The characteristics of colorectal cancer in patients older than 80 years. J Korean Soc Coloproctol 2007;23:490-496.
    CrossRef
  6. Basili G, Lorenzetti L, Biondi G, et al. Colorectal cancer in the elderly: is there a role for safe and curative surgery? ANZ J Surg 2008;78:466-470.
    Pubmed CrossRef
  7. Cress RD, Morris C, Ellison GL, Goodman MT. Secular changes in colorectal cancer incidence by subsite, stage at diagnosis, and race/ethnicity, 1992-2001. Cancer 2006;107:1142-1152.
    Pubmed CrossRef
  8. Mulcahy HE, Patchett SE, Daly L, O’Donoghue DP. Prognosis of elderly patients with large bowel cancer. Br J Surg 1994;81:736-738.
    Pubmed CrossRef
  9. Chang GJ, Skibber JM, Feig BW, Rodriguez-Bigas M. Are we undertreating rectal cancer in the elderly? An epidemiologic study. Ann Surg 2007;246:215-221.
    Pubmed KoreaMed CrossRef
  10. Gerges FJ, Kanazi GE, Jabbour-Khoury SI. Anesthesia for laparoscopy: a review. J Clin Anesth 2006;18:67-78.
    Pubmed CrossRef
  11. She WH, Poon JT, Fan JK, Lo OS, Law WL. Outcome of laparoscopic colectomy for cancer in elderly patients. Surg Endosc 2012 [Epub ahead of print].
    Pubmed
  12. Lee YS, Lee IK, Kang WK, et al. Laparoscopic surgery for colorectal cancer in elderly patients. J Korean Soc Coloproctol 2007;23:257-261.
    CrossRef
  13. Lee SH, Kang BM, Lee KY, Park SI, Lee SH. Laparoscopic colorectal surgery is safe for elderly patients over the age of
  14. J Korean Soc Endosc Laparosc Surg 2011;14:68-73.
  15. Akiyoshi T, Kuroyanagi H, Oya M, et al. Short-term outcomes of laparoscopic rectal surgery for primary rectal cancer in elderly patients: is it safe and beneficial? J Gastrointest Sur g 2009;13:1614-1618.
    Pubmed CrossRef
  16. Centers for Disease Control and Prevention. NHSN Patient Safety Component Manual 2012;9:1-15. http://cdc.gov/nhsn/TOC_PSCManual.html/ [Online].
  17. Dindo D, Demartines N, Clavien PA. Classification of surgica l complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240:205-213.
    Pubmed KoreaMed CrossRef
  18. Jung JM, Jung SA, Kim SE, Kang MJ, Shim KN, Kim KH, et al. Favorable factors for sur vival in elderly patients with colorectal cancer. Korean J Med 2009;76:701-712.
  19. Cummings LC, Delaney CP, Coope r GS. Laparoscopic versus open colectomy for colon cancer in an older population: a cohort study. World J Surg Oncol 2012;10:1-10.
    Pubmed KoreaMed CrossRef
  20. Tei M, Ikeda M, Haraguchi N, et al. Postoperative complications in elderly patients with colorectal cancer comparison of open and laparoscopic surgical procedures. Surg Laparosc Endosc Percutan Tech 2009;19:488-492.
    Pubmed CrossRef
  21. Roscio F, Bertoglio C, De Luca A, Frigerio A, Galli F, Scandroglio I. Outcomes of laparo scopic surgery for colorectal cancer in elderly patients. JSLS 2011;15:315-321.
    Pubmed KoreaMed CrossRef
  22. Allardyce RA, Bagshaw PF, Fr ampton CM, et al. Australasian laparoscopic colon cancer study shows that elderly patients may benefit from lower postoperative complication rates following laparoscopic versus open resection. Br J Surg 2010;97:86-91.
    Pubmed CrossRef
  23. Grailey K, Markar SR, Karthikesalingam A, Aboud R, Ziprin P, Faiz O. Laparoscopic versus open colorectal resection in the elderly Population. Surg Endos c 2012 [Epub ahead of print].
    Pubmed
  24. Weeks JC, Nelson H, Gelber S, Sargent D, Schroeder G, Clinical Outcomes of Surgical Therapy (COST) Study Group. Short-term quality of life outcomes following laparoscopic assisted colectomy vs open colectomy for colon cancr; a randomized trial. JAMA 2002;287:321-328.
    Pubmed CrossRef
  25. Gonzalez R, Smith CD, Mason E, Duncan T, Wilson R, Miller J, et al. Consequences of Conversion in Laparoscopic Colorectal Surgery. Dis Colon Rectum 2006;49:197-204.
    Pubmed CrossRef
  26. White I, Greenberg R, Itah R, Inbar R, Schneebaum S, Avital S. Impact of conversion on short and long-term outcome in laparoscopic resection of curable colorectal cancer. JSLS 2011;15:182-187.
    Pubmed KoreaMed CrossRef

Article

Original Article

J Minim Invasive Surg 2012; 15(4): 126-132

Published online December 15, 2012 https://doi.org/10.7602/jmis.2012.15.4.126

Copyright © The Korean Society of Endo-Laparoscopic & Robotic Surgery.

대장암 진단을 받은 75세 이상의 환자군에서의 복강경 수술의 유용성

이강산ㆍ김영완ㆍ김주희ㆍ권현준ㆍ김익용

연세대학교 원주의과대학 외과학교실

Received: August 24, 2012; Revised: October 13, 2012; Accepted: October 16, 2012

Can Elderly Patients Older than 75 Years with Colorectal Cancer Tolerate Planned Laparoscopic Surgery?

Kang San Lee, M.D., Young Wan Kim, M.D., Joo Hee Kim, M.D., Hyun Jun Kwon, R.N., Ik Yong Kim, M.D.

Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea

Correspondence to:Ik Yong Kim
Department of Surgery, Yonsei University Wonju College of Medicine, 162, Ilsan-dong, Wonju 220-701, Korea
Tel:+82-33-741-0575, Fax:+82-33-744-6604 E-mail:iykim@yonsei.ac.kr

Received: August 24, 2012; Revised: October 13, 2012; Accepted: October 16, 2012

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose: Colorectal resection for elderly patients is associated with significant morbidity and mortality. It is still unclear whether or not laparoscopic colorectal resection (Lap CR) is indicated in elderly patients. The aim of this study is to evaluate the outcome of colonic surgery in elderly patients and to assess the feasibility and safety of laparoscopic colorectal surgery in elderly patients.
Methods: Patient characteristics and perioperative and pathologic data on 295 patients who underwent Lap CR for cancer from Jan. 2004 to Aug. 2011 were prospectively collected. Exclusion criteria were emergency and palliative bypass surgery. Outcomes for elderly patients (≥75 years) were compared with those of younger patients (<75 years).
Results: In comparison of 257 younger patients (<75 years, median age 61 years), 38 elderly patients (≥75 years, median age 79 years) showed a greater proportion off emale gender (52.6% vs. 37.0%, p=0.065) and American Society of Anesthesiologists score 2∼3 (97.3% vs.42.0%, p<0.001). No differences in tumor location, median operative time, conversion rate, duration of hospital stay, and perioperative complications (23.7% vs. 30.0%, p=0.427) were observed between the two groups. Distributions of American Joint Committee on Cancer stages and number of harvested lymph nodes were comparable between groups.
Conclusion: Although elderly patients are more likely to be affected by co morbidities, postoperative outcome in this group after Lap CR is comparable with that of younger patients. Use of Lap CR in elderly patients is safe, and is associated with a low morbidity. It should be also regarded as the optimal approach for very elderly patients.

Keywords: Colorectal cancer, Laparoscopy, Elderly, Safety, Complication

References

  1. Statistics Korea. Population Projections for Korea: 2010-2060 , Statistical Publications 2012;B81303;378. http://kostatat.go.kr
  2. Ministry for Heath, Welfare a nd Family Affairs. Annual report of cancer incidence 2009 and survival 1999 ∼ 2009 in Korea. 2011;10154.
  3. Mamidanna R, Eid-Arimoku L, Almoudaris AM, et al. Poor 1-year survival in elderly patients undergoing non elective colorectal resection. Dis Co lon Rectum 2012;55:788-796.
    Pubmed CrossRef
  4. Minardi A, Sittig KM, Zibari GB, McDonald JC. Colorectal cancer in the young patient. Am Surg 1998;64:849-853.
    Pubmed
  5. Lee JM, Kim HC, Park IJ, Kim DD, Yu CS, Kim JC. The characteristics of colorectal cancer in patients older than 80 years. J Korean Soc Coloproctol 2007;23:490-496.
    CrossRef
  6. Basili G, Lorenzetti L, Biondi G, et al. Colorectal cancer in the elderly: is there a role for safe and curative surgery? ANZ J Surg 2008;78:466-470.
    Pubmed CrossRef
  7. Cress RD, Morris C, Ellison GL, Goodman MT. Secular changes in colorectal cancer incidence by subsite, stage at diagnosis, and race/ethnicity, 1992-2001. Cancer 2006;107:1142-1152.
    Pubmed CrossRef
  8. Mulcahy HE, Patchett SE, Daly L, O’Donoghue DP. Prognosis of elderly patients with large bowel cancer. Br J Surg 1994;81:736-738.
    Pubmed CrossRef
  9. Chang GJ, Skibber JM, Feig BW, Rodriguez-Bigas M. Are we undertreating rectal cancer in the elderly? An epidemiologic study. Ann Surg 2007;246:215-221.
    Pubmed KoreaMed CrossRef
  10. Gerges FJ, Kanazi GE, Jabbour-Khoury SI. Anesthesia for laparoscopy: a review. J Clin Anesth 2006;18:67-78.
    Pubmed CrossRef
  11. She WH, Poon JT, Fan JK, Lo OS, Law WL. Outcome of laparoscopic colectomy for cancer in elderly patients. Surg Endosc 2012 [Epub ahead of print].
    Pubmed
  12. Lee YS, Lee IK, Kang WK, et al. Laparoscopic surgery for colorectal cancer in elderly patients. J Korean Soc Coloproctol 2007;23:257-261.
    CrossRef
  13. Lee SH, Kang BM, Lee KY, Park SI, Lee SH. Laparoscopic colorectal surgery is safe for elderly patients over the age of
  14. J Korean Soc Endosc Laparosc Surg 2011;14:68-73.
  15. Akiyoshi T, Kuroyanagi H, Oya M, et al. Short-term outcomes of laparoscopic rectal surgery for primary rectal cancer in elderly patients: is it safe and beneficial? J Gastrointest Sur g 2009;13:1614-1618.
    Pubmed CrossRef
  16. Centers for Disease Control and Prevention. NHSN Patient Safety Component Manual 2012;9:1-15. http://cdc.gov/nhsn/TOC_PSCManual.html/ [Online].
  17. Dindo D, Demartines N, Clavien PA. Classification of surgica l complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240:205-213.
    Pubmed KoreaMed CrossRef
  18. Jung JM, Jung SA, Kim SE, Kang MJ, Shim KN, Kim KH, et al. Favorable factors for sur vival in elderly patients with colorectal cancer. Korean J Med 2009;76:701-712.
  19. Cummings LC, Delaney CP, Coope r GS. Laparoscopic versus open colectomy for colon cancer in an older population: a cohort study. World J Surg Oncol 2012;10:1-10.
    Pubmed KoreaMed CrossRef
  20. Tei M, Ikeda M, Haraguchi N, et al. Postoperative complications in elderly patients with colorectal cancer comparison of open and laparoscopic surgical procedures. Surg Laparosc Endosc Percutan Tech 2009;19:488-492.
    Pubmed CrossRef
  21. Roscio F, Bertoglio C, De Luca A, Frigerio A, Galli F, Scandroglio I. Outcomes of laparo scopic surgery for colorectal cancer in elderly patients. JSLS 2011;15:315-321.
    Pubmed KoreaMed CrossRef
  22. Allardyce RA, Bagshaw PF, Fr ampton CM, et al. Australasian laparoscopic colon cancer study shows that elderly patients may benefit from lower postoperative complication rates following laparoscopic versus open resection. Br J Surg 2010;97:86-91.
    Pubmed CrossRef
  23. Grailey K, Markar SR, Karthikesalingam A, Aboud R, Ziprin P, Faiz O. Laparoscopic versus open colorectal resection in the elderly Population. Surg Endos c 2012 [Epub ahead of print].
    Pubmed
  24. Weeks JC, Nelson H, Gelber S, Sargent D, Schroeder G, Clinical Outcomes of Surgical Therapy (COST) Study Group. Short-term quality of life outcomes following laparoscopic assisted colectomy vs open colectomy for colon cancr; a randomized trial. JAMA 2002;287:321-328.
    Pubmed CrossRef
  25. Gonzalez R, Smith CD, Mason E, Duncan T, Wilson R, Miller J, et al. Consequences of Conversion in Laparoscopic Colorectal Surgery. Dis Colon Rectum 2006;49:197-204.
    Pubmed CrossRef
  26. White I, Greenberg R, Itah R, Inbar R, Schneebaum S, Avital S. Impact of conversion on short and long-term outcome in laparoscopic resection of curable colorectal cancer. JSLS 2011;15:182-187.
    Pubmed KoreaMed CrossRef

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