Original Article

J Minim Invasive Surg 2015; 18(4): 113-120

Published online December 15, 2015

https://doi.org/10.7602/jmis.2015.18.4.113

© The Korean Society of Endo-Laparoscopic & Robotic Surgery

The Long-term Outcomes of Endoscopic Stenting as a Bridge to Elective Surgery in Patients with Colorectal Cancer Obstruction as Compared with Emergency Surgery

Yu-Jin Choi, M.D., Jin Kim, M.D., Han-Deok Kwak, M.D., Dong-Woo Kang, M.D., Se-Jin Baek, M.D., Jung-Myun Kwak, M.D.,
Seon-Hahn Kim, M.D.

Department of Surgery, Korea University College of Medicine, Seoul, Korea

Received: August 31, 2015; Revised: October 1, 2015; Accepted: October 13, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Purpose: The aim of this study was to compare the short- and long-term outcomes between stent placement as a bridge to surgery and emergency surgery for obstructive colon cancer.
Methods: Patients who underwent surgery for left colon cancer and rectal cancer with total obstruction from September 2006 to October 2014 were enrolled. Data for the stent placement and emergency surgery groups were compared.
Results: Of the 67 patients with total obstruction, 53 patients were treated with stent placement and 14 patients were treated with emergency surgery. Significant differences were observed for surgical approach, type of operation, and combined resection. Use of minimally invasive surgery (MIS) was higher (88.6 vs. 42.9%, p<0.001) in the stent placement (SP) group, and combined resection (5.9 vs. 37.5%, p<0.001) was higher in the emergency surgery (EM) group. In the SP group, resection and anastomosis accounted for the largest proportion (92.5%) and in the EM group, Hartmann’s procedure was most common (57.1%) (p<0.001). There were no significant differences in other operative outcomes or in postoperative courses. Five-year overall survival was 96.0 and 77.8% (p=0.311) in the SP and EM groups, respectively. Five-year disease-free survival for local recurrence in the SP and EM groups was 90.0 and 88.9% (p=0.904).
Conclusion: Stent placement as a bridge to surgery can be performed safely and represents an alternative to emergency surgery with good short-term results. Stent placement as a bridge to surgery is also comparable to emergency surgery in long-term outcomes.

Keywords Self-expanding metallic stent (SEMS), Colorectal neoplasm, Obstruction, Local recurrence

  1. Cancer statics in Korea. Division of cancer registration & surveillance of national cancer center 2012.
  2. Fan YB, Cheng YS, Chen NW, Xu HM, Yang Z, Wang Y, Huang YY, Zheng Q. Clinical application of self-expanding metallic stent in the management of acute left-sided colorectal malignant obstruction. World J Gastroenterol 2006;12:755-759.
    CrossRef
  3. A Maffioli AB, G Manes, D Cavallo, S Callioni, PG Danell. Colonic stenting in the management of malignant intestinal obstruction in elderly patients. BMC Surg 2013.
    CrossRef
  4. Villar JM, Martinez AP, Villegas MT, Muffak K, Mansilla A, Garrote D, Ferron JA. Surgical options for malignant left-sided colonic obstruction. Surg Today 2005;35:275-281.
    CrossRef
  5. Zorcolo L, Covotta L, Carlomagno N, Bartolo DC. Safety of primary anastomosis in emergency colo-rectal surgery. Colorectal Dis 2003;5:262-269.
    CrossRef
  6. Dohmoto M, Rupp KD, Hohlbach G. Endoscopically-implanted prosthesis in rectal carcinoma. Dtsch Med Wochenschr 1990;115: 915.
  7. Geraghty J, Sarkar S, Cox T, Lal S, Willert R, Ramesh J, Bodger K, Carlson GL. Management of large bowel obstruction with self-expanding metal stents. A multicentre retrospective study of factors determining outcome. Colorectal Dis 2014;16:476-483.
    CrossRef
  8. Jimenez-Perez J, Casellas J, Garcia-Cano J, Vandervoort J, Garcia-Escribano OR, Barcenilla J, Delgado AA, Goldberg P, Gonzalez-Huix F, Vazquez-Astray E, Meisner S. Colonic stenting as a bridge to surgery in malignant large-bowel obstruction: a report from two large multinational registries. Am J Gastroenterol 2011;106:2174-2180.
    CrossRef
  9. Jury G, Amieva L, Dolan M, Fagalde RL, Naiderman D, Pastorino M, Jury R. Neoplasic colonic obstruction: resolution with self- expanding metallic stents. Acta Gastroenterol Latinoam 2014;44: 33-38.
  10. Kavanagh DO, Nolan B, Judge C, Hyland JM, Mulcahy HE, O'Connell PR, Winter DC, Doherty GA. A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction. Dis Colon Rectum 2013;56:433-440.
    CrossRef
  11. Maruthachalam K, Lash GE, Shenton BK, Horgan AF. Tumour cell dissemination following endoscopic stent insertion. Br J Surg 2007;94:1151-1154.
    CrossRef
  12. Malgras B, Brulle L, Lo Dico R, El Marjou F, Robine S, Therwath A, Pocard M. Insertion of a stent in obstructive colon cancer can induce a metastatic process in an experimental murine model. Ann Surg Oncol 2015.
    CrossRef
  13. Sloothaak DA, van den Berg MW, Dijkgraaf MG, Fockens P, Tanis PJ, van Hooft JE, Bemelman WA, collaborative Dutch Stent-In study g. Oncological outcome of malignant colonic obstruction in the Dutch Stent-In 2 trial. Br J Surg 2014;101:1751- 1757.
    CrossRef
  14. Parkin E, Khurshid M, Ravi S, Linn T. Surgical access through the stoma for laparoscopic reversal of Hartmann procedures. Surg Laparosc Endosc Percutan Tech 2013;23:41-44.
    CrossRef
  15. Lin FL, Boutros M, Da Silva GM, Weiss EG, Lu XR, Wexner SD. Hartmann reversal: obesity adversely impacts outcome. Dis Colon Rectum 2013;56:83-90.
    CrossRef
  16. Van de Wall BJ, Draaisma WA, Schouten ES, Broeders IA, Consten EC. Conventional and laparoscopic reversal of the Hartmann procedure: a review of literature. J Gastrointest Surg 2010;14:743-752.
    CrossRef
  17. Zimmermann M, Hoffmann M, Laubert T, Meyer KF, Jungbluth T, Roblick UJ, Bruch HP, Schloricke E. Laparoscopic versus open reversal of a Hartmann procedure: a single-center study. World J Surg 2014;38:2145-2152.
    CrossRef
  18. Aydin C, Olmez A, Isik S, Sumer F, Kayaalp C. Reversal of the Hartmann procedure through only a stomal orifice. Am Surg 2011; 77:694-696.
  19. Cheung HY, Chung CC, Tsang WW, Wong JC, Yau KK, Li MK. Endolaparoscopic approach vs conventional open surgery in the treatment of obstructing left-sided colon cancer: a randomized controlled trial. Arch Surg 2009;144:1127-1132.
    CrossRef
  20. Yamamoto S, Inomata M, Katayama H, Mizusawa J, Etoh T, Konishi F, Sugihara K, Watanabe M, Moriya Y, Kitano S, Japan Clinical Oncology Group Colorectal Cancer Study G. Short-term surgical outcomes from a randomized controlled trial to evaluate laparoscopic and open D3 dissection for stage II/III colon cancer: Japan Clinical Oncology Group Study JCOG 0404. Ann Surg 2014; 260:23-30.
    CrossRef
  21. Zambouri A. Preoperative evaluation and preparation for anesthesia and surgery. Hippokratia 2007;11:13-21.
  22. Yamauchi H, Sobue K. Anesthesia preoperative preparation of muscular dystrophy. Masui 2010;59:1093-1095.
  23. Shida D, Tagawa K, Inada K, Nasu K, Seyama Y, Maeshiro T, Miyamoto S, Inoue S, Umekita N. Enhanced recovery after surgery (ERAS) protocols for colorectal cancer in Japan. BMC Surg 2015;15:90.
    CrossRef
  24. Spanjersberg WR, van Sambeeck JD, Bremers A, Rosman C, van Laarhoven CJ. Systematic review and meta-analysis for laparoscopic versus open colon surgery with or without an ERAS programme. Surg Endosc 2015.
    CrossRef
  25. Kim JS, Hur H, Min BS, Sohn SK, Cho CH, Kim NK. Oncologic outcomes of self-expanding metallic stent insertion as a bridge to surgery in the management of left-sided colon cancer obstruction: comparison with nonobstructing elective surgery. World J Surg 2009;33:1281-1286.
    CrossRef
  26. Saida Y, Sumiyama Y, Nagao J, Uramatsu M. Long-term prognosis of preoperative "bridge to surgery" expandable metallic stent insertion for obstructive colorectal cancer: comparison with emergency operation. Dis Colon Rectum 2003;46:S44-S49.
  27. Choi JM, Lee C, Han YM, Lee M, Choi YH, Jang DK, Im JP, Kim SG, Kim JS, Jung HC. Long-term oncologic outcomes of endoscopic stenting as a bridge to surgery for malignant colonic obstruction: comparison with emergency surgery. Surg Endosc 2014;28:2649-2655.
    CrossRef
  28. Fregonese D, Naspetti R, Ferrer S, Gallego J, Costamagna G, Dumas R, Campaioli M, Morante AL, Mambrini P, Meisner S, Repici A, Andreo L, Masci E, Mingo A, Barcenilla J, Petruzziello L. Ultraflex precision colonic stent placement as a bridge to surgery in patients with malignant colon obstruction. Gastrointest Endosc 2008;67:68-73.
    CrossRef
  29. Won Y, Lee SL, Ku YM, Kim KT, Won HS, An CH. Clinical effect of double coaxial self-expandable metallic stent in manage- ment of malignant colon obstruction. Diagn Interv Radiol 2015;21: 167-172.
    CrossRef

Article

Original Article

J Minim Invasive Surg 2015; 18(4): 113-120

Published online December 15, 2015 https://doi.org/10.7602/jmis.2015.18.4.113

Copyright © The Korean Society of Endo-Laparoscopic & Robotic Surgery.

The Long-term Outcomes of Endoscopic Stenting as a Bridge to Elective Surgery in Patients with Colorectal Cancer Obstruction as Compared with Emergency Surgery

Yu-Jin Choi, M.D., Jin Kim, M.D., Han-Deok Kwak, M.D., Dong-Woo Kang, M.D., Se-Jin Baek, M.D., Jung-Myun Kwak, M.D.,
Seon-Hahn Kim, M.D.

Department of Surgery, Korea University College of Medicine, Seoul, Korea

Received: August 31, 2015; Revised: October 1, 2015; Accepted: October 13, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose: The aim of this study was to compare the short- and long-term outcomes between stent placement as a bridge to surgery and emergency surgery for obstructive colon cancer.
Methods: Patients who underwent surgery for left colon cancer and rectal cancer with total obstruction from September 2006 to October 2014 were enrolled. Data for the stent placement and emergency surgery groups were compared.
Results: Of the 67 patients with total obstruction, 53 patients were treated with stent placement and 14 patients were treated with emergency surgery. Significant differences were observed for surgical approach, type of operation, and combined resection. Use of minimally invasive surgery (MIS) was higher (88.6 vs. 42.9%, p<0.001) in the stent placement (SP) group, and combined resection (5.9 vs. 37.5%, p<0.001) was higher in the emergency surgery (EM) group. In the SP group, resection and anastomosis accounted for the largest proportion (92.5%) and in the EM group, Hartmann’s procedure was most common (57.1%) (p<0.001). There were no significant differences in other operative outcomes or in postoperative courses. Five-year overall survival was 96.0 and 77.8% (p=0.311) in the SP and EM groups, respectively. Five-year disease-free survival for local recurrence in the SP and EM groups was 90.0 and 88.9% (p=0.904).
Conclusion: Stent placement as a bridge to surgery can be performed safely and represents an alternative to emergency surgery with good short-term results. Stent placement as a bridge to surgery is also comparable to emergency surgery in long-term outcomes.

Keywords: Self-expanding metallic stent (SEMS), Colorectal neoplasm, Obstruction, Local recurrence

References

  1. Cancer statics in Korea. Division of cancer registration & surveillance of national cancer center 2012.
  2. Fan YB, Cheng YS, Chen NW, Xu HM, Yang Z, Wang Y, Huang YY, Zheng Q. Clinical application of self-expanding metallic stent in the management of acute left-sided colorectal malignant obstruction. World J Gastroenterol 2006;12:755-759.
    CrossRef
  3. A Maffioli AB, G Manes, D Cavallo, S Callioni, PG Danell. Colonic stenting in the management of malignant intestinal obstruction in elderly patients. BMC Surg 2013.
    CrossRef
  4. Villar JM, Martinez AP, Villegas MT, Muffak K, Mansilla A, Garrote D, Ferron JA. Surgical options for malignant left-sided colonic obstruction. Surg Today 2005;35:275-281.
    CrossRef
  5. Zorcolo L, Covotta L, Carlomagno N, Bartolo DC. Safety of primary anastomosis in emergency colo-rectal surgery. Colorectal Dis 2003;5:262-269.
    CrossRef
  6. Dohmoto M, Rupp KD, Hohlbach G. Endoscopically-implanted prosthesis in rectal carcinoma. Dtsch Med Wochenschr 1990;115: 915.
  7. Geraghty J, Sarkar S, Cox T, Lal S, Willert R, Ramesh J, Bodger K, Carlson GL. Management of large bowel obstruction with self-expanding metal stents. A multicentre retrospective study of factors determining outcome. Colorectal Dis 2014;16:476-483.
    CrossRef
  8. Jimenez-Perez J, Casellas J, Garcia-Cano J, Vandervoort J, Garcia-Escribano OR, Barcenilla J, Delgado AA, Goldberg P, Gonzalez-Huix F, Vazquez-Astray E, Meisner S. Colonic stenting as a bridge to surgery in malignant large-bowel obstruction: a report from two large multinational registries. Am J Gastroenterol 2011;106:2174-2180.
    CrossRef
  9. Jury G, Amieva L, Dolan M, Fagalde RL, Naiderman D, Pastorino M, Jury R. Neoplasic colonic obstruction: resolution with self- expanding metallic stents. Acta Gastroenterol Latinoam 2014;44: 33-38.
  10. Kavanagh DO, Nolan B, Judge C, Hyland JM, Mulcahy HE, O'Connell PR, Winter DC, Doherty GA. A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction. Dis Colon Rectum 2013;56:433-440.
    CrossRef
  11. Maruthachalam K, Lash GE, Shenton BK, Horgan AF. Tumour cell dissemination following endoscopic stent insertion. Br J Surg 2007;94:1151-1154.
    CrossRef
  12. Malgras B, Brulle L, Lo Dico R, El Marjou F, Robine S, Therwath A, Pocard M. Insertion of a stent in obstructive colon cancer can induce a metastatic process in an experimental murine model. Ann Surg Oncol 2015.
    CrossRef
  13. Sloothaak DA, van den Berg MW, Dijkgraaf MG, Fockens P, Tanis PJ, van Hooft JE, Bemelman WA, collaborative Dutch Stent-In study g. Oncological outcome of malignant colonic obstruction in the Dutch Stent-In 2 trial. Br J Surg 2014;101:1751- 1757.
    CrossRef
  14. Parkin E, Khurshid M, Ravi S, Linn T. Surgical access through the stoma for laparoscopic reversal of Hartmann procedures. Surg Laparosc Endosc Percutan Tech 2013;23:41-44.
    CrossRef
  15. Lin FL, Boutros M, Da Silva GM, Weiss EG, Lu XR, Wexner SD. Hartmann reversal: obesity adversely impacts outcome. Dis Colon Rectum 2013;56:83-90.
    CrossRef
  16. Van de Wall BJ, Draaisma WA, Schouten ES, Broeders IA, Consten EC. Conventional and laparoscopic reversal of the Hartmann procedure: a review of literature. J Gastrointest Surg 2010;14:743-752.
    CrossRef
  17. Zimmermann M, Hoffmann M, Laubert T, Meyer KF, Jungbluth T, Roblick UJ, Bruch HP, Schloricke E. Laparoscopic versus open reversal of a Hartmann procedure: a single-center study. World J Surg 2014;38:2145-2152.
    CrossRef
  18. Aydin C, Olmez A, Isik S, Sumer F, Kayaalp C. Reversal of the Hartmann procedure through only a stomal orifice. Am Surg 2011; 77:694-696.
  19. Cheung HY, Chung CC, Tsang WW, Wong JC, Yau KK, Li MK. Endolaparoscopic approach vs conventional open surgery in the treatment of obstructing left-sided colon cancer: a randomized controlled trial. Arch Surg 2009;144:1127-1132.
    CrossRef
  20. Yamamoto S, Inomata M, Katayama H, Mizusawa J, Etoh T, Konishi F, Sugihara K, Watanabe M, Moriya Y, Kitano S, Japan Clinical Oncology Group Colorectal Cancer Study G. Short-term surgical outcomes from a randomized controlled trial to evaluate laparoscopic and open D3 dissection for stage II/III colon cancer: Japan Clinical Oncology Group Study JCOG 0404. Ann Surg 2014; 260:23-30.
    CrossRef
  21. Zambouri A. Preoperative evaluation and preparation for anesthesia and surgery. Hippokratia 2007;11:13-21.
  22. Yamauchi H, Sobue K. Anesthesia preoperative preparation of muscular dystrophy. Masui 2010;59:1093-1095.
  23. Shida D, Tagawa K, Inada K, Nasu K, Seyama Y, Maeshiro T, Miyamoto S, Inoue S, Umekita N. Enhanced recovery after surgery (ERAS) protocols for colorectal cancer in Japan. BMC Surg 2015;15:90.
    CrossRef
  24. Spanjersberg WR, van Sambeeck JD, Bremers A, Rosman C, van Laarhoven CJ. Systematic review and meta-analysis for laparoscopic versus open colon surgery with or without an ERAS programme. Surg Endosc 2015.
    CrossRef
  25. Kim JS, Hur H, Min BS, Sohn SK, Cho CH, Kim NK. Oncologic outcomes of self-expanding metallic stent insertion as a bridge to surgery in the management of left-sided colon cancer obstruction: comparison with nonobstructing elective surgery. World J Surg 2009;33:1281-1286.
    CrossRef
  26. Saida Y, Sumiyama Y, Nagao J, Uramatsu M. Long-term prognosis of preoperative "bridge to surgery" expandable metallic stent insertion for obstructive colorectal cancer: comparison with emergency operation. Dis Colon Rectum 2003;46:S44-S49.
  27. Choi JM, Lee C, Han YM, Lee M, Choi YH, Jang DK, Im JP, Kim SG, Kim JS, Jung HC. Long-term oncologic outcomes of endoscopic stenting as a bridge to surgery for malignant colonic obstruction: comparison with emergency surgery. Surg Endosc 2014;28:2649-2655.
    CrossRef
  28. Fregonese D, Naspetti R, Ferrer S, Gallego J, Costamagna G, Dumas R, Campaioli M, Morante AL, Mambrini P, Meisner S, Repici A, Andreo L, Masci E, Mingo A, Barcenilla J, Petruzziello L. Ultraflex precision colonic stent placement as a bridge to surgery in patients with malignant colon obstruction. Gastrointest Endosc 2008;67:68-73.
    CrossRef
  29. Won Y, Lee SL, Ku YM, Kim KT, Won HS, An CH. Clinical effect of double coaxial self-expandable metallic stent in manage- ment of malignant colon obstruction. Diagn Interv Radiol 2015;21: 167-172.
    CrossRef

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